146255-66-5

146255-66-5 structure

Name: (RS)-3,5-DHPG
Chemical Name: (S)-3,5-dihydroxyphenylglycine
CAS Number: 146255-66-5
Molecular Formula: C₈H₉NO₄
Molecular Weight: 183.16100
Catalog: Biochemical Amino acids and their derivatives Glycine derivatives
Create Date: 2018-04-10 08:00:00
Modify Date: 2025-08-25 10:51:32
DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D[2].

Name	(S)-3,5-dihydroxyphenylglycine
Synonyms	(RS)-3,5-DHPG tert-Butylisopentanal HEXANAL,3,5,5-TRIMETHYL Isononylaldehyde 3,5,5-Trimethylcapronaldehyde 3,5,5,-trimethylhexanal Hexanal,3,5,5-trimethl

Description	DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR
Target	mGluR 1 mGluR 5
References	[1]. Winder DG, et al. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64(2):592-9. [2]. Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118(4):1035-43.