138154-39-9
138154-39-9 structure
- Name: C-1311
- Chemical Name: 5-((2-(diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one
- CAS Number: 138154-39-9
- Molecular Formula: C20H22N4O2
- Molecular Weight: 350.41400
- Create Date: 2018-11-24 08:29:14
- Modify Date: 2024-01-03 18:28:56
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Symadex, also known as imidazoacridone; XLS-002 and C-1311, is a member of the novel imidazoacridinone family of anticancer agents. Imidazoacridone has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 at the EC(99) dose delayed progression of cells through the S phase which was followed by G2 arrest. C-1311 does not induce rapid apoptosis in HT-29 cells, instead drug exposure leads to prolonged G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe.
| Name | 5-((2-(diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one |
|---|---|
| Synonyms |
5-[[(diethylamino)ethyl]amino]-8-hydroxyimidazo[4,5,1-de]-acridine-6-one
C 1311 XLS-002 6H-Imidazo(4,5,1-de)acridin-6-one,5-((2-(diethylamino)ethyl)amino)-8-hydroxy 5-((2-(Diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one |
| Density | 1.32g/cm3 |
|---|---|
| Boiling Point | 605.8ºC at 760mmHg |
| Molecular Formula | C20H22N4O2 |
| Molecular Weight | 350.41400 |
| Flash Point | 320.2ºC |
| Exact Mass | 350.17400 |
| PSA | 69.87000 |
| LogP | 2.97100 |
| Vapour Pressure | 2.86E-15mmHg at 25°C |
| Index of Refraction | 1.68 |
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138154-39-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6597 - 6611 |
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138154-39-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6597 - 6611 |
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138154-39-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6597 - 6611 |
|
~%
138154-39-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6597 - 6611 |
|
~%
138154-39-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6597 - 6611 |
| Precursor 3 | |
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| DownStream 0 | |