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636-79-3

636-79-3 structure
636-79-3 structure
  • Name: 3-Pyridinecarboxylicacid, hydrochloride (1:1)
  • Chemical Name: pyridine-3-carboxylic acid,hydrochloride
  • CAS Number: 636-79-3
  • Molecular Formula: C6H6ClNO2
  • Molecular Weight: 159.57000
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-07-26 07:17:35
  • Modify Date: 2024-01-01 18:19:33
  • Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].
Name pyridine-3-carboxylic acid,hydrochloride
Synonyms chloro nicotinic acid
Nicotinic acid,hydrochloride
3-carboxypyridinium chloride
pyridine-3-carboxylic chloride
Niacin hydrochloride
Niacin HCl
3-Pyridinecarboxylic acid,hydrochloride
Pyridine-3-carboxylic acid hydrochloride
Description Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].
Related Catalog
Target

Microbial Metabolite
In Vitro Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1]. Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2]. RT-PCR[1] Cell Line: Cumulus cells and oocytes of prepubertal gilts Concentration: 600 μM Incubation Time: 42 hours Result: Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX. Cell Proliferation Assay[2] Cell Line: Rat ascites hepatoma cell line of AH109A Concentration: 0-40 μM Incubation Time: 24 hours Result: Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.
In Vivo Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3]. Animal Model: Male C57BL/6 mice[3] Dosage: 3-300 mg/kg Administration: Subcutaneous injection; once Result: Induced vasodilation in a dose-dependent manner.
References

[1]. Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18.

[2]. Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8.

[3]. Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7.
Boiling Point 292.5ºC at 760 mmHg
Melting Point 236.6ºC
Molecular Formula C6H6ClNO2
Molecular Weight 159.57000
Flash Point 130.7ºC
Exact Mass 159.00900
PSA 50.19000
LogP 1.58180
59-67-6 structure

59-67-6
5324-30-1 structure

5324-30-1

~0%

1401997-95-2 structure

1401997-95-2
636-79-3 structure

636-79-3
Literature: Costantino, Ferdinando; Sassi, Paola; Geppi, Marco; Taddei, Marco Crystal Growth and Design, 2012 , vol. 12, # 11 p. 5462 - 5470
59-67-6 structure

59-67-6

~%

636-79-3 structure

636-79-3
Literature: Arai, Kunizo; Shimizu, Sakae; Yamamoto, Yuzuru Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 4 p. 1005 - 1012
10400-19-8 structure

10400-19-8

~%

636-79-3 structure

636-79-3
Literature: Arai, Kunizo; Shimizu, Sakae; Yamamoto, Yuzuru Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 4 p. 1005 - 1012

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title: CAS No. 636-79-3 | Chemsrc address: https://www.chemsrc.com/en/baike/337999.html

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