Nanjing Peptide Biotech Ltd
China
Product Name: β-MSH (human)
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Zhejiang Hangyu API Co., Ltd
China
Product Name: β-MSH (human)
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

17908-57-5

17908-57-5 structure

17908-57-5 structure

Name: β-MSH (human) trifluoroacetate salt
Chemical Name: β-Melanocyte Stimulating Hormone human
CAS Number: 17908-57-5
Molecular Formula: C₁₁₈H₁₇₄N₃₄O₃₅S
Molecular Weight: 2660.92000
Catalog: Biochemical Peptide
Create Date: 2018-09-22 20:10:19
Modify Date: 2024-01-02 20:31:57
β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist.

Name	β-Melanocyte Stimulating Hormone human
Synonyms	MFCD00167548 β-Melanocyte stimulating hormone human \|A-MSH human β-Melanocyte Stimulating Hormone (MSH), human

Description	β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor Research Areas >> Neurological Disease Peptides Research Areas >> Metabolic Disease
Target	Melanocortin[1]
In Vitro	β-Melanocyte Stimulating Hormone is a powerful anti-inflammatory agent which effect is brought by activation of the central MC3/MC4 receptors and thereby inhibits NO production by inhibiting the translocation of transcription factor NF-κB to the nuclei of the brain cells and decreasing iNOS expression[1]. β-Melanocyte Stimulating Hormone has significantly higher at human MC4-R transfected into CHO cells (Ki=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (Ki=22.5±2.3 nM)[2].
In Vivo	β-Melanocyte Stimulating Hormone suppresses LPS-induced nuclear translocation of the transcription factor NF-κB, and inhibits the expression of inducible nitric oxide synthase, and the following nitric oxide overproduction in the brain[1].β-Melanocyte Stimulating Hormone is a key ligand at the MC4-R populations that regulate feeding, and that inhibition of tonic release of β-MSH is one mechanism contributing to hunger in under-feeding[2].
Animal Admin	Mice[1] Male ICR mice weighing 23-25 g are housed under standard conditions (21-23°C, 12 h light-dark cycle) with unlimited access to food and water. The NO contents in the mouse forebrains are measured 6 h after drug administration using an electron paramagnetic resonance (EPR) method. β-Melanocyte Stimulating Hormone is administered intracisternaly (i.c.) with or without LPS, in a total injection volume of 10 μL (i.e., saline or 10 μL LPS with β-Melanocyte Stimulating Hormone ranging from 1 to 3 nM per animal). Control animals receive i.c. injection of 10 μL saline. The mice then receive intraperitoneal injections of spin trap reagents, i.e., 400 mg/kg DETC followed by subcutaneous injections of ferrous citrate (40 mg/kg ferrous sulphate+200 mg/kg sodium citrate, prepared directly in the syringe just before use), 0.5 h before decapitation. Thus, the spin trap reagents are administered 5.5 h after the LPS and peptide administration, when decapitation is performed 6 h after the start of the experiment. After that the forebrains are dissected and immediately frozen in liquid nitrogen.
References	[1]. Muceniece R, et al. Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling. J Neuroimmunol. 2005 Dec;169(1-2):13-9. [2]. Harrold JA, et al. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. 2003 Mar;24(3):397-405.

Molecular Formula	C₁₁₈H₁₇₄N₃₄O₃₅S
Molecular Weight	2660.92000
Exact Mass	2659.26000
PSA	1146.64000
LogP	2.49690
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3