167498-29-5
167498-29-5 structure
- Name: Cathepsin L inhibitor
- Chemical Name: z-fy-cho
- CAS Number: 167498-29-5
- Molecular Formula: C26H26N2O5
- Molecular Weight: 446.49500
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
- Create Date: 2018-12-11 17:29:52
- Modify Date: 2025-08-25 13:00:38
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Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor[1][2].
| Name | z-fy-cho |
|---|---|
| Synonyms |
z-phe-tyr-cho
z-phe-tyr-aldehyde cathepsin l inhibitor ii |
| Description | Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Cathepsin L (CTSL)[1] |
| In Vitro | Z-FY-CHO (10 µM, for 1 h) pretreatment alleviated cell death induced by 6-OHDA. Z-FY-CHO inhibits the increase in CTSL protein expression in 6-OHDA-treated SH-SY5Y cells. Treatment with Z-FY-CHO caused more LC3-II and less P62 expression in SH-SY5Y cells treated with 6-OHDA, indicating enhancing autophagy activity, and Z-FY-CHO blocks activation of caspase-3 and PARP[1]. Treatment with the specific cathepsin L inhibitor Z-FY-CHO (10 μM) or transfection with cathepsin L shRNA significantly increased the radiosensitivity of U251 cells. Both suppression and knockdown of cathepsin L in U251 cells increased irradiation-induced DNA damage and G2/M phase cell cycle arrest. Both suppression and knockdown of cathepsin L in U251 cells also increased irradiation-induced apoptosis, as shown by the increased levels of Bax and decreased levels of Bcl-2[2]. |
| In Vivo | Intraperitoneal administration of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks suppresses bone weight loss dose dependently in the ovariectomized mouse, experimental model of osteoporosis. Z-FY-CHO acts as a bone resorption suppressor through the inhibition of collagen degradation[3]. |
| References |
| Molecular Formula | C26H26N2O5 |
|---|---|
| Molecular Weight | 446.49500 |
| Exact Mass | 446.18400 |
| PSA | 104.73000 |
| LogP | 3.93790 |