300816-11-9

300816-11-9 structure

Name: script
Chemical Name: 4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxybutanamide
CAS Number: 300816-11-9
Molecular Formula: C₁₆H₁₄N₂O₄
Molecular Weight: 298.293
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2018-12-29 05:53:03
Modify Date: 2024-01-08 11:24:03
Nullscript is a negative control for Scriptaid. Nullscript is a known inactive analog of Scriptaid[1]. Scriptaid is a representative HDAC inhibitor[2]. Nullscript inhibits Cryptosporidium (C. parvum) growth with the IC50 value of 2.1 μM[3].

Name	4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxybutanamide
Synonyms	MFCD00405081 1H-Benz[de]isoquinoline-2(3H)-butanamide, N-hydroxy-1,3-dioxo- 4-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxybutanamide

Description	Nullscript is a negative control for Scriptaid. Nullscript is a known inactive analog of Scriptaid[1]. Scriptaid is a representative HDAC inhibitor[2]. Nullscript inhibits Cryptosporidium (C. parvum) growth with the IC50 value of 2.1 μM[3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Min Tong, et al. Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. Biochem Pharmacol. 2006 Sep 14;72(6):701-9. [2]. Judith Clancy Keen, et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. Breast Cancer Res Treat. 2003 [3]. Fumi Murakoshi, et al. Nullscript inhibits Cryptosporidium and Toxoplasma growth. Int J Parasitol Drugs Drug Resist. 2020 Dec;14:159-166.

Safety Phrases	22-24/25