Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dihydrokavain
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dihydrokavain
Price: ￥1768.0/10mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: dihydrokavain
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dihydrokavain
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

587-63-3

587-63-3 structure

587-63-3 structure

Name: Dihydrokavain
Chemical Name: (S)-(+)-7,8-Dihydrokavain
CAS Number: 587-63-3
Molecular Formula: C₁₄H₁₆O₃
Molecular Weight: 232.275
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2018-05-03 08:00:00
Modify Date: 2025-08-25 17:58:24
Dihydrokavain is one of the six major kavalactones found in the kava plant; appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.

Name	(S)-(+)-7,8-Dihydrokavain
Synonyms	2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethyl)- 4-Methoxy-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one Dihydrokavain dihydrokawain 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6- (2-phenylethyl)-, (S)- (6S)-4-Methoxy-6-(2-phenylethyl)-5,6-dihydro-2H-pyran-2-one 5,6-Dihydro-4-methoxy-6-(2-phenylethyl)-2H-pyran-2-one 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-(2-phenylethyl)-, (6S)-

Description	Dihydrokavain is one of the six major kavalactones found in the kava plant; appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Others
References	[1]. Feltenstein MW, et al. Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. Phytother Res. 2003 Mar;17(3):210-6.

Density	1.1±0.1 g/cm3
Boiling Point	413.6±45.0 °C at 760 mmHg
Melting Point	56-60ºC
Molecular Formula	C₁₄H₁₆O₃
Molecular Weight	232.275
Flash Point	175.6±23.3 °C
Exact Mass	232.109940
PSA	35.53000
LogP	1.95
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.544
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0517700

CHEMICAL NAME :: 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-phenethyl-

CAS REGISTRY NUMBER :: 587-63-3

LAST UPDATED :: 199206

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H16-O3

MOLECULAR WEIGHT :: 232.30

WISWESSER LINE NOTATION :: T6OV CUTJ DO1 F1U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 177,261,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 138,505,1962

RIDADR	NONH for all modes of transport

Precursor 8
77-78-1 182950-96-5 30414-58-5 1449-46-3
152203-65-1 100-39-0 35217-21-1 862464-32-2
DownStream 0

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