228546-92-7

228546-92-7 structure

Name: CR 665
Chemical Name: (2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2R)-5-(diaminomethylideneamino)-1-oxo-1-(pyridin-4-ylmethylamino)pentan-2-yl]hexanamide
CAS Number: 228546-92-7
Molecular Formula: C₃₆H₄₉N₉O₄
Molecular Weight: 671.83200
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2017-04-07 22:17:01
Modify Date: 2025-08-22 12:26:01
CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].

Name	(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2R)-5-(diaminomethylideneamino)-1-oxo-1-(pyridin-4-ylmethylamino)pentan-2-yl]hexanamide
Synonyms	UNII-3BX9UG06GG D-Argininamide,D-phenylalanyl-D-phenylalanyl-D-norleucyl-N-(4-pyridinylmethyl) CR665

Description	CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM. CR 665 can be used for the research of peripheral pain[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	C50: 10.9 nM (κ-opioid)[1]
In Vitro	CR 665 exhibits high peripheral to central nervous system (CNS) selectivity[1]. CR 665 can activate the kappa opioid receptor with EC50 value of 10.9 nM[1].