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58749-23-8

58749-23-8 structure
58749-23-8 structure
  • Name: Licochalcone B
  • Chemical Name: (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
  • CAS Number: 58749-23-8
  • Molecular Formula: C16H14O5
  • Molecular Weight: 286.279
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-09-23 07:22:55
  • Modify Date: 2025-08-27 16:25:18
  • Licochalcone B is an extract from the root of Glycyrrhiza inflate. Licochalcone B inhibits amyloid β (Aβ42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions[1].
Name (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Synonyms 2-methoxy-3,4,4'-trihydroxychalcone
Licochalcone B
Licochalcon B
(2E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
licochalcone
Description Licochalcone B is an extract from the root of Glycyrrhiza inflate. Licochalcone B inhibits amyloid β (Aβ42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions[1].
References

[1]. Cao Y, et al. Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease. Nat Prod Res. 2018 Oct 22:1-4.
Density 1.4±0.1 g/cm3
Boiling Point 550.5±50.0 °C at 760 mmHg
Melting Point 196-197ºC
Molecular Formula C16H14O5
Molecular Weight 286.279
Flash Point 208.5±23.6 °C
Exact Mass 286.084137
PSA 86.99000
LogP 2.57
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.684
Storage condition 2-8C
2144-08-3 structure

2144-08-3

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58749-23-8 structure

58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
85699-02-1 structure

85699-02-1

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58749-23-8 structure

58749-23-8

Literature: Islam, Azizul; Khan, Saeed Ahmad; Krishnamurti, M. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 10 p. 965 - 966
85699-00-9 structure

85699-00-9

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58749-23-8 structure

58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
85698-99-3 structure

85698-99-3

~%

58749-23-8 structure

58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
85699-01-0 structure

85699-01-0

~%

58749-23-8 structure

58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
99-93-4 structure

99-93-4

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58749-23-8 structure

58749-23-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 181 - 185
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