120042-14-0
120042-14-0 structure
- Name: L-Azidohomoalanine
- Chemical Name: (2S)-2-amino-4-azidobutanoic acid
- CAS Number: 120042-14-0
- Molecular Formula: C4H8N4O2
- Molecular Weight: 144.13200
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-08-21 10:08:30
- Modify Date: 2025-08-25 15:45:23
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L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | (2S)-2-amino-4-azidobutanoic acid |
|---|---|
| Synonyms |
4-Azido-homoalanine
2(S)-Amino-4-azido-butanoic Acid azidohomoalanine Butanoic acid,2-amino-4-azido-,(2S) AmbotzHAA5730 L-Azidohomoalanine 4-Azido-L-2-aminobutyrate azodohomoalanine L-4-azido-2-aminobutanoic acid |
| Description | L-Azidohomoalanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 220-223ºC |
|---|---|
| Molecular Formula | C4H8N4O2 |
| Molecular Weight | 144.13200 |
| Exact Mass | 144.06500 |
| PSA | 113.07000 |
| LogP | 0.25176 |
|
~98%
120042-14-0 |
| Literature: Roth, Stefanie; Thomas, Neil R. Synlett, 2010 , # 4 art. no. D28009ST, p. 607 - 609 |
|
~%
120042-14-0 |
| Literature: European Journal of Organic Chemistry, , # 31 p. 5308 - 5314 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |