345893-91-6
345893-91-6 structure
- Name: SUN B8155
- Chemical Name: SUN-B 8155,5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridone
- CAS Number: 345893-91-6
- Molecular Formula: C14H15N3O3
- Molecular Weight: 273.28700
- Catalog: Signaling Pathways GPCR/G Protein CGRP Receptor
- Create Date: 2017-02-25 07:12:07
- Modify Date: 2024-01-14 11:38:31
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SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis[1].
| Name | SUN-B 8155,5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridone |
|---|---|
| Synonyms | 5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridinone |
| Description | SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis[1]. |
|---|---|
| Related Catalog | |
| In Vitro | SUN B8155 (1-1000 μM; 1 hour) stimulates intracellular cAMP formation in T47D cells in a concentration-dependent manner; the concentration of synthesized cAMP increased by approximately 42-fold at the highest concentration. SUN B8155 also stimulates cAMP formation in the rat osteogenic sarcoma-derived cell line, UMR106-06[1]. SUN B8155 does not stimulate cAMP formation in CHO/hPTHR or parental CHO cells, but fully stimulates cAMP formation in CHO/hCTR cells in a concentration-dependent manner with an EC50 of 21 μM[1]. |
| In Vivo | SUN B8155 (100 mg/kg; i.p.) results in a significant reduction of serum calcium concentration by approximately 9% at 30 min after administration. Human CT also reduces serum calcium in a dose-dependent manner at 30 min (0.1 and 0.3 μg/kg) and 60 min (0.3 μg/kg) after administration[1]. |
| References |
| Density | 1.34g/cm3 |
|---|---|
| Boiling Point | 419ºC at 760 mmHg |
| Molecular Formula | C14H15N3O3 |
| Molecular Weight | 273.28700 |
| Flash Point | 207.2ºC |
| Exact Mass | 273.11100 |
| PSA | 100.84000 |
| LogP | 2.40370 |
| Index of Refraction | 1.637 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| RIDADR | UN 2811 6.1 / PGIII |