271246-66-3

271246-66-3 structure

Name: MMK1
Chemical Name: mmk 1
CAS Number: 271246-66-3
Molecular Formula: C₇₅H₁₂₃N₁₉O₁₈S
Molecular Weight: 1610.96000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2017-07-15 18:00:38
Modify Date: 2024-01-03 21:44:17
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK-1 potently activated phagocytic leukocytes and could enhance Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity[1][2][3][4].

Name	mmk 1

Description	MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK-1 potently activated phagocytic leukocytes and could enhance Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Calcium Channel
In Vitro	MMK-1 induces calcium mobilization in human FPRL1-transfected HEK 293 (FPRL1/293) cells with a 50% effective concentration (EC50) at 2 nM[1]. MMK1 (1 μM; for 4 h) induces selective migration of FPR2-expressing RBL-2H3 cells[3].
In Vivo	MMK1 (10-1000 pmol; ICV; 20 min before the test) exerts an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse[4]. Animal Model: Four-week-old male ddY mice[4] Dosage: 10, 100, 1000 pmol/mouse Administration: ICV; 20 min before the test Result: Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.
References	[1]. C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7. [2]. Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. [3]. Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664. [4]. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20.

Molecular Formula	C₇₅H₁₂₃N₁₉O₁₈S
Molecular Weight	1610.96000
Exact Mass	1609.90000
PSA	639.38000
LogP	5.44370

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