- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Docosanedioic acid
- Price: ￥816.0/1g ￥2746.0/5g ￥326.0/250mg ￥4576.0/10g
- Purity: 95.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: Docosanedioic acid
- Price: ￥Inquiry/10kg
- Purity: 95.0%
- Stocking Period: Inquiry
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: Docosanedioic acid
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Docosanedioic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
505-56-6
505-56-6 structure
- Name: Docosanedioic acid
- Chemical Name: docosanedioic acid
- CAS Number: 505-56-6
- Molecular Formula: C22H42O4
- Molecular Weight: 370.566
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-09-15 19:56:28
- Modify Date: 2024-01-04 17:23:14
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Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
| Name | docosanedioic acid |
|---|---|
| Synonyms |
1,22-Docosanedioic acid
1,20-Eicosanedicarboxylic acid Phellogenic acid docosanedicarboxylic acid MFCD00002807 docosandioic acid EINECS 204-010-8 Phelogenic acid Docosanedioic acid 1,22-Docosanedoic acid Docosandisaeure Felogenic acid |
| Description | Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 527.0±23.0 °C at 760 mmHg |
| Melting Point | 72-80 °C(lit.) |
| Molecular Formula | C22H42O4 |
| Molecular Weight | 370.566 |
| Flash Point | 286.6±19.1 °C |
| Exact Mass | 370.308319 |
| PSA | 74.60000 |
| LogP | 8.24 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.474 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | UN 1824 |
| WGK Germany | 3 |
| HS Code | 2917190090 |
| Precursor 10 | |
|---|---|
| DownStream 6 | |
![5-Methyl-4-[[3-methyl-1-(4-methylphenyl)-5-oxo-2H-pyrazol-4-yl]-(2-nitrophenyl)methyl]-2-(4-methylphenyl)-4H-pyrazol-3-one structure](https://www.chemsrc.com/caspic/328/5634-23-1.png)
| HS Code | 2917190090 |
|---|---|
| Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |