825649-28-3

825649-28-3 structure

Name: JNJ-20788560
Chemical Name: 9-[(1R,5S)-8-azabicyclo[3.2.1]octan-3-ylidene]-N,N-diethylxanthene-3-carboxamide
CAS Number: 825649-28-3
Molecular Formula: C₂₅H₂₈N₂O₂
Molecular Weight: 388.50200
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2016-12-14 22:59:37
Modify Date: 2024-02-01 11:21:47
JNJ-20788560 is a selective and orally active delta opioid receptor agonist with an affinity of 2.0 nM for DOR (rat brain cortex binding assay). JNJ-20788560 also is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. JNJ-20788560 can be used for the research of the relief of inflammatory hyperalgesia[1].

Name	9-[(1R,5S)-8-azabicyclo[3.2.1]octan-3-ylidene]-N,N-diethylxanthene-3-carboxamide
Synonyms	unii-99hyh9k6mz

Description	JNJ-20788560 is a selective and orally active delta opioid receptor agonist with an affinity of 2.0 nM for DOR (rat brain cortex binding assay). JNJ-20788560 also is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. JNJ-20788560 can be used for the research of the relief of inflammatory hyperalgesia[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
References	[1]. Codd EE, et al. JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. J Pharmacol Exp Ther. 2009 Apr;329(1):241-51.