Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: pre-Calcitriol PTAD Adduct
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

86307-44-0

86307-44-0 structure

Name: pre-Calcitriol PTAD Adduct
Chemical Name: pre-Calcitriol PTAD Adduct
CAS Number: 86307-44-0
Molecular Formula: C₃₅H₄₉N₃O₅
Molecular Weight: 591.78100
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2019-01-04 23:15:22
Modify Date: 2025-08-20 19:23:47
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).IC50 value:Target: vitamin D receptorCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Name	pre-Calcitriol PTAD Adduct
Synonyms	Impurity C of Calcitriol Calcitriol Impurity 3

Description	Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).IC50 value:Target: vitamin D receptorCalcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Cancer
References	[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004) [2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. [3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23. [4]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

Molecular Formula	C₃₅H₄₉N₃O₅
Molecular Weight	591.78100
Exact Mass	591.36700
PSA	109.62000
LogP	5.05860
Storage condition	2-8℃

86307-43-9

~73%

86307-44-0

Literature: Vanmaele, L.; Clerq, P. J. de; Vandewalle, M. Tetrahedron, 1985 , vol. 41, # 1 p. 141 - 144