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  • Product Name: Isotetrandrine
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Related CAS#:
477-57-6 1263-79-2
23495-89-8 70191-83-2

477-57-6

477-57-6 structure
477-57-6 structure
  • Name: Isotetrandrine
  • Chemical Name: Isosinomenin A
  • CAS Number: 477-57-6
  • Molecular Formula: C38H42N2O6
  • Molecular Weight: 622.750
  • Catalog: Natural product Alkaloid
  • Create Date: 2018-03-29 08:00:00
  • Modify Date: 2024-01-02 20:49:38
  • Isotetrandrine is a bioactive component in S. acutum[1].
Name Isosinomenin A
Synonyms O,O'-Dimethylobamegine
isotetrandine
O-Methylberbamine
O,O'-Dimethylstepholine
6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman
Isosinomenine A
6,7,12,6'-tetramethoxy-2,2'-dimethyl-berbamane
1R,1'S isotetrandrine
1-isotetrandrine
Description Isotetrandrine is a bioactive component in S. acutum[1].
Related Catalog
In Vitro Fangchi, derived from the rhizoma of S. acutum and the radix of S. tetrandra and S. acutum, has been widely used for the treatment of rheumatic arthritis[1].
References

[1]. Kim, Ji Hee et al. UHPLC Separation of Structurally Diverse Markers in Fangchi Species. (2013).
Density 1.2±0.1 g/cm3
Boiling Point 710.5±60.0 °C at 760 mmHg
Melting Point 180-182ºC
Molecular Formula C38H42N2O6
Molecular Weight 622.750
Flash Point 175.8±30.1 °C
Exact Mass 622.304260
PSA 61.86000
LogP 3.55
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.586

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX7285000
CHEMICAL NAME :
1-Isotetrandrine
CAS REGISTRY NUMBER :
477-57-6
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C38-H42-N2-O6
MOLECULAR WEIGHT :
622.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(5),176S,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976
Hazard Codes Xi
1472-62-4 structure

1472-62-4

~%

477-57-6 structure

477-57-6
Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151
17934-80-4 structure

17934-80-4

~%

477-57-6 structure

477-57-6
Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151
66277-16-5 structure

66277-16-5

~%

477-57-6 structure

477-57-6
Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151
186581-53-3 structure

186581-53-3
38769-07-2 structure

38769-07-2

~%

477-57-6 structure

477-57-6
Literature: Kupchan; Liepa; Baxter; Hintz Journal of Organic Chemistry, 1973 , vol. 38, # 10 p. 1846 - 1852
186581-53-3 structure

186581-53-3

~%

477-57-6 structure

477-57-6
Literature: Kugo Yakugaku Zasshi, 1959 , vol. 79, p. 322 Chem.Abstr., 1959 , p. 17161
186581-53-3 structure

186581-53-3
436-77-1 structure

436-77-1

~%

477-57-6 structure

477-57-6
Literature: Mitscher,L.A. et al. Journal of the Chemical Society [Section] D: Chemical Communications, 1971 , p. 589 - 590

Chemsrc provides CAS#:477-57-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 477-57-6 | Chemsrc address: https://www.chemsrc.com/en/baike/252753.html

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