DC Chemicals Limited
China
Product Name: Isotetrandrine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isosinomenin A
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

477-57-6

477-57-6 structure

Name: Isotetrandrine
Chemical Name: Isosinomenin A
CAS Number: 477-57-6
Molecular Formula: C₃₈H₄₂N₂O₆
Molecular Weight: 622.750
Catalog: Natural product Alkaloid
Create Date: 2018-03-29 08:00:00
Modify Date: 2025-08-22 11:45:32
Isotetrandrine is a bioactive component in S. acutum[1].

Name	Isosinomenin A
Synonyms	O,O'-Dimethylobamegine isotetrandine O-Methylberbamine O,O'-Dimethylstepholine 6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman Isosinomenine A 6,7,12,6'-tetramethoxy-2,2'-dimethyl-berbamane 1R,1'S isotetrandrine 1-isotetrandrine

Description	Isotetrandrine is a bioactive component in S. acutum[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Fangchi, derived from the rhizoma of S. acutum and the radix of S. tetrandra and S. acutum, has been widely used for the treatment of rheumatic arthritis[1].
References	[1]. Kim, Ji Hee et al. UHPLC Separation of Structurally Diverse Markers in Fangchi Species. (2013).

Density	1.2±0.1 g/cm3
Boiling Point	710.5±60.0 °C at 760 mmHg
Melting Point	180-182ºC
Molecular Formula	C₃₈H₄₂N₂O₆
Molecular Weight	622.750
Flash Point	175.8±30.1 °C
Exact Mass	622.304260
PSA	61.86000
LogP	3.55
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.586

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX7285000

CHEMICAL NAME :: 1-Isotetrandrine

CAS REGISTRY NUMBER :: 477-57-6

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C38-H42-N2-O6

MOLECULAR WEIGHT :: 622.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(5),176S,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976

Hazard Codes	Xi

1472-62-4

477-57-6

Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151

17934-80-4

477-57-6

Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151

66277-16-5

477-57-6

Literature: Bhakuni; Singh; Jain Tetrahedron, 1980 , vol. 36, # 14 p. 2149 - 2151

186581-53-3

38769-07-2

477-57-6

Literature: Kupchan; Liepa; Baxter; Hintz Journal of Organic Chemistry, 1973 , vol. 38, # 10 p. 1846 - 1852

186581-53-3

477-57-6

Literature: Kugo Yakugaku Zasshi, 1959 , vol. 79, p. 322 Chem.Abstr., 1959 , p. 17161

186581-53-3

436-77-1

477-57-6

Literature: Mitscher,L.A. et al. Journal of the Chemical Society [Section] D: Chemical Communications, 1971 , p. 589 - 590

Precursor 5
1472-62-4 17934-80-4 66277-16-5 186581-53-3
436-77-1
DownStream 2
3423-07-2 479-37-8

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