462-20-4

462-20-4 structure

Name: Dihydrolipoic acid
Chemical Name: dihydrolipoic acid
CAS Number: 462-20-4
Molecular Formula: C₈H₁₆O₂S₂
Molecular Weight: 208.341
Catalog: analytical chemistry Standard Food and cosmetics standards
Create Date: 2018-09-03 11:38:32
Modify Date: 2024-01-03 11:31:01
Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical[1]. Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression[2].

Name	dihydrolipoic acid
Synonyms	DL-Dihydrolipoic acid dihydrothiocticacid Dihydroliponsure (±)-dihydrolipoic acid Gamma-Lipoic Acid 6,8-Dimercaptooctanoic acid 6,8-Disulfanyloctanoic acid dihydro-thiocticaci dihydrolipoate Octanoic acid, 6,8-dimercapto- DIHYDROLIPOIC ACID usafxr-12 dihydro-lipoicaci DHLA 6,8-Dihydrothioctic acid reducedlipoicacid

Description	Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical[1]. Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression[2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Dihydrolipoic Acid is an antioxidant. DHLA is capable of scavenging •OH radicals and scavenging superoxide radical anions with a rate constant of 3.3×105 M-1 s-1. Dihydrolipoic Acid is an excellent antioxidant, and that is very important because O2•- is a relatively mild oxidant that is therefore much more selective and can be useful to discriminate between the antioxidant capacities of different substrates[1].
In Vivo	Dihydrolipoic Acid (DHLA) treatment exerts preventive effects in LPS-induced sickness behavior rats. Dihydrolipoic Acid increases the expression of ERK, Nrf2, and HO-1 but decreases the ROS generation levels and reduces the expression of NLRP3, caspase-1, and IL-1β in LPS-induced sickness behavior rats. Dihydrolipoic Acid is a reduced form of α-lipoic acid (LA) that can decrease oxidative stress and act as a strong antioxidant[2]. Dihydrolipoic Acid treatment reverses the LPS-induced sickness behavior[2]. Animal Model: Adult male Sprague-Dawley (SD) rats (weight, 200-220 g)[2] Dosage: 15 mg/kg, 30 mg/kg, 60 mg/kg Administration: Injected intraperitoneally daily Result: Treatment with 30 mg/kg and 60 mg/kg improved the body weight gain as compared to the LPS group.
References	[1]. Romina Castañeda-Arriaga, et al. Lipoic acid and dihydrolipoic acid. A comprehensive theoretical study of their antioxidant activity supported by available experimental kinetic data. J Chem Inf Model. 2014 Jun 23;54(6):1642-52. [2]. Hetao Bian, et al. Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. J Neuroinflammation. 2020 May 25;17(1):166.

Density	1.1±0.1 g/cm3
Boiling Point	360.8±32.0 °C at 760 mmHg
Melting Point	60ºC
Molecular Formula	C₈H₁₆O₂S₂
Molecular Weight	208.341
Flash Point	172.0±25.1 °C
Exact Mass	208.059174
PSA	114.90000
LogP	2.07
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.527
Storage condition	+2C to +8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RH0525000

CHEMICAL NAME :: Octanoic acid, 6,8-dimercapto-

CAS REGISTRY NUMBER :: 462-20-4

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H16-O2-S2

MOLECULAR WEIGHT :: 208.36

WISWESSER LINE NOTATION :: SH2YSH4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RH0525000
HS Code	2930909090

Precursor 0
DownStream 5
60-24-2 1077-28-7 69819-89-2 27565-41-9
131760-67-3

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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