Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Lofexidine
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Lofexidine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
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31036-80-3

31036-80-3 structure

31036-80-3 structure

Name: Lofexidine
Chemical Name: lofexidine
CAS Number: 31036-80-3
Molecular Formula: C₁₁H₁₂Cl₂N₂O
Molecular Weight: 259.132
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-09-03 01:15:31
Modify Date: 2025-08-25 18:45:18
Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].

Name	lofexidine
Synonyms	MFCD00865915 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole 2-(a-(2,6-dichlorophenoxy)ethyl)2-imidazoline Lofexidinum [INN-Latin] Lofexidina 1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro- Britlofex Lofexidine (±)-2-[1-(2,6-Dichlorophenoxy)ethyl]-2-imidazoline Lofexidinum Lofexidine [INN:BAN] Lofexidina [INN-Spanish] 2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline UNII:UI82K0T627 (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene 2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole rac-2-[1-(2,6-dichlorophenoxy)ethyl]-1,3-diazacyclopent-2-ene

Description	Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	α2-receptor[1][2].
References	[1]. Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9(11):1371-7. [2]. Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44(2):343-51.

Density	1.4±0.1 g/cm3
Boiling Point	421.5±35.0 °C at 760 mmHg
Melting Point	215-225 °C
Molecular Formula	C₁₁H₁₂Cl₂N₂O
Molecular Weight	259.132
Flash Point	208.7±25.9 °C
Exact Mass	258.032654
PSA	33.62000
LogP	3.59
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.611
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2568000

CHEMICAL NAME :: 2-Imidazoline 2-(1-(2,6-dichlorophenoxy)ethyl)-

CAS REGISTRY NUMBER :: 31036-80-3

LAST UPDATED :: 198912

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H12-Cl2-N2-O

MOLECULAR WEIGHT :: 259.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8320 ug/kg

SEX/DURATION :: female 8-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 9,559,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8320 ug/kg

SEX/DURATION :: female 8-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 9,551,1988

Safety Phrases	S24/25
WGK Germany	3

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