65813-55-0
65813-55-0 structure
- Name: 1-Oxo Ibuprofen
- Chemical Name: 1-Oxo Ibuprofen
- CAS Number: 65813-55-0
- Molecular Formula: C13H16O3
- Molecular Weight: 220.26400
- Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
- Create Date: 2018-12-27 12:27:30
- Modify Date: 2025-08-24 21:04:11
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1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].
| Name | 1-Oxo Ibuprofen |
|---|---|
| Synonyms | 2-[4-(2-methylpropanoyl)phenyl]propanoic acid |
| Description | 1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.107g/cm3 |
|---|---|
| Boiling Point | 377.952ºC at 760 mmHg |
| Melting Point | 85-87ºC |
| Molecular Formula | C13H16O3 |
| Molecular Weight | 220.26400 |
| Flash Point | 196.555ºC |
| Exact Mass | 220.11000 |
| PSA | 54.37000 |
| LogP | 2.71340 |
| Index of Refraction | 1.528 |
| Storage condition | -20°C Freezer |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2918300090 |
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65813-55-0 |
| Literature: Journal of the American Chemical Society, , vol. 130, # 5 p. 1628 - 1637 |
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65813-55-0 |
| Literature: US6359182 B1, ; Page column 53 ; |
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~1%
Detail
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| Literature: Journal of the Chemical Society, Chemical Communications, , # 8 p. 601 - 602 |
| Precursor 1 | |
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| DownStream 0 | |
| HS Code | 2918300090 |
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| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |