18486-69-6

18486-69-6 structure

Name: (−)-Myrtenal
Chemical Name: (-)-myrtenal
CAS Number: 18486-69-6
Molecular Formula: C₁₀H₁₄O
Molecular Weight: 150.22
Catalog: Flavors and spices Synthetic spice Aldehyde Nonenal
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-01-03 17:28:57
(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats[1][2].

Name	(-)-myrtenal
Synonyms	(1R,5S)-6,6-dimethyl-bicyclo[3.3.1]hept-2-en-2-carbaldehyde FEMA 3395 l-Myrtenal (R)-6,6-dimethylbicyclo[3.3.1]hept-2-en-2-carboxaldehyde (-)-(1R,5S)-Myrtenal (-)-Myrtenal (1R)-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-EN-2-CARBOXAL-DEHYDE (-)-1R-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-carboxaldehyde (1R)-2-PINEN-10-AL MYRTENAL,-(-)-(SG) (R)-mirtenal MYRTENAL,-(-)

Description	(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	(−)-Myrtenal ((1R)-(−)-Myrtenal; 0.1-5 mM; for 24 h) exerts strong cytotoxic effect (IC50 = 5.3 mM) on human colon tumour (HT29) and human normal colon epithelial cells (CCD 841 CoTr)[1].
In Vivo	(−)-Myrtenal ((1R)-(−)-Myrtenal; orally; 80 mg/kg/day for 28 days) reveals decreased the levels of plasma glucose, improved the plasma insulin levels, up-regulation of IRS2, Akt and GLUT2 in liver and IRS2, Akt and GLUT4 protein expression in skeletal muscle in diabetic rats induced by single intraperitoneal injection of Streptozotocin (STZ) (40 mg/kg bw)[2].
References	[1]. Mariusz Trytek, et al. Biological activity of oxygenated pinene derivatives on human colon normal and carcinoma cells. Flavour and Fragrance Journal, Volume33, Issue6, November 2018. [2]. Ayyasamy Rathinam, et al. Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats. Chem Biol Interact. 2016 Aug 25;256:161-6.

Density	0.988 g/mL at 20ºC(lit.)
Boiling Point	220-221ºC(lit.)
Molecular Formula	C₁₀H₁₄O
Molecular Weight	150.22
Flash Point	174 °F
Exact Mass	150.10400
PSA	17.07000
LogP	2.17770
Appearance	Liquid \| Clear colorless to yellow
Index of Refraction	n20/D 1.504
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves
Safety Phrases	23-24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	DT5180000