940291-10-1

940291-10-1 structure

Name: IDR-1
Chemical Name: (2S)-1-formyl-N-[(2S)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide,propane
CAS Number: 940291-10-1
Molecular Formula: C₆₅H₁₁₈N₁₈O₁₅
Molecular Weight: 242.31500
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-12-07 14:34:32
Modify Date: 2024-01-30 11:51:54
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release[1][2].

Name	(2S)-1-formyl-N-[(2S)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide,propane
Synonyms	IDR-1

Description	IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Monisha G Scott, et al. An Anti-Infective Peptide That Selectively Modulates the Innate Immune Response. Nat Biotechnol. 2007 Apr;25(4):465-72. [2]. Man Hou, et al. Antimicrobial Peptide LL-37 and IDR-1 Ameliorate MRSA Pneumonia in Vivo. Cell Physiol Biochem. 2013;32(3):614-23.