184025-19-2
184025-19-2 structure
- Name: Ciproxifan Maleate
- Chemical Name: (Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
- CAS Number: 184025-19-2
- Molecular Formula: C20H22N2O6
- Molecular Weight: 386.398
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2018-12-27 11:05:42
- Modify Date: 2025-08-31 12:03:46
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Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.IC50 value: Target: H3 receptorIn vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
| Name | (Z)-but-2-enedioic acid,cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone |
|---|---|
| Synonyms |
FUB 359 maleate salt
Ciproxifan maleate cc-128 Ciproxifan moleate cyclopropyl{4-[3-(1H-imidazol-4-yl)propoxy]phenyl}methanone (2Z)-but-2-enedioate (1:1) Cyclopropyl{4-[3-(1H-imidazol-5-yl)propoxy]phenyl}methanone (2Z)-2-butenedioate (1:1) Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt FUB 359 maleate salt methanone, cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxy]phenyl]-, (2Z)-2-butenedioate (1:1) FUB359 maleate Methanone, cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-, (2Z)-2-butenedioate (1:1) Ciproxifan (maleate) |
| Description | Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.IC50 value: Target: H3 receptorIn vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders. |
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| Related Catalog | |
| References |
| Boiling Point | 743.6ºC at 760 mmHg |
|---|---|
| Molecular Formula | C20H22N2O6 |
| Molecular Weight | 386.398 |
| Flash Point | 403.5ºC |
| Exact Mass | 386.147797 |
| PSA | 129.58000 |
| LogP | 2.72580 |
| Vapour Pressure | 3.22E-23mmHg at 25°C |
| Storage condition | -20℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H317-H319-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |