2397562-43-3

2397562-43-3 structure

Name: KPZ560
Chemical Name: KPZ560
CAS Number: 2397562-43-3
Molecular Formula: C₂₆H₂₁N₅O₃S₂
Molecular Weight: 515.61
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2024-03-08 13:14:18
Modify Date: 2024-03-08 13:14:18
KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC50s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF[1].

Name	KPZ560

Description	KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC50s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:12 nM (IC50) HDAC2:68 nM (IC50)
References	[1]. Yukihiro Itoh, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. J Med Chem. 2023 Oct 17. doi: 10.1021/acs.jmedchem.3c01095. Online ahead of print.

Molecular Formula	C₂₆H₂₁N₅O₃S₂
Molecular Weight	515.61