149418-38-2

149418-38-2 structure

Name: Feralolide
Chemical Name: Feralolide
CAS Number: 149418-38-2
Molecular Formula: C₁₈H₁₆O₇
Molecular Weight: 344.32
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2024-01-09 07:10:40
Modify Date: 2024-01-09 07:10:40
Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC50s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory[1].

Name	Feralolide

Description	Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with IC50s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease, potentially restoring and enhancing memory[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 55 μg/mL (AChE), 52 μg/mL (BuChE)[1]
References	[1]. Khan I, et al. Antiamnesic Effects of Feralolide Isolated from Aloe vera Resin Miller against Learning Impairments Induced in Mice. Antioxidants (Basel). 2023 Jan 10;12(1):161.

Molecular Formula	C₁₈H₁₆O₇
Molecular Weight	344.32