2131025-75-5

2131025-75-5 structure

Name: Eplontersen sodium
Chemical Name: Eplontersen sodium
CAS Number: 2131025-75-5
Molecular Formula: C₂₉₆H₄₁₇N₇₇Na₂₀O₁₅₆P₂₀S₁₃
Molecular Weight: 9046.10
Catalog: Research Areas Neurological Disease
Create Date: 2024-03-18 12:59:25
Modify Date: 2025-08-25 14:27:47
Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases[1][2][3].

Name	Eplontersen sodium

Description	Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases[1][2][3].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Aimo A, et al. RNA-targeting and gene editing therapies for transthyretin amyloidosis. Nat Rev Cardiol. 2022 Mar 23. [2]. Diep JK, et al. Population pharmacokinetic/pharmacodynamic modelling of eplontersen, an antisense oligonucleotide in development for transthyretin amyloidosis. Br J Clin Pharmacol. 2022 Jul 22. [3]. Prakash Thazha P, et al. Antisense oligonucleotides to hepatitis B virus RNA or transthyretin mRNA conjugated with N-acetylgalactosamine targeting moieties: World Intellectual Property Organization, WO2014179627[P]. 2014-11-06.

Molecular Formula	C₂₉₆H₄₁₇N₇₇Na₂₀O₁₅₆P₂₀S₁₃
Molecular Weight	9046.10