177931-17-8

177931-17-8 structure

Name: Sauchinone
Chemical Name: (5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro- 5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one
CAS Number: 177931-17-8
Molecular Formula: C₂₀H₂₀O₆
Molecular Weight: 356.369
Catalog: Biochemical Plant extracts
Create Date: 2018-06-13 09:28:08
Modify Date: 2025-09-06 09:44:09
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].

Name	(5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro- 5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one
Synonyms	(5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one Sauchinone 5H-Benzo[kl][1,3]dioxolo[4,5-b]-1,3-dioxolo[4,5-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)-

Description	Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	p65 I-kappaBalpha
In Vitro	Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells[1]. Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively[1].
References	[1]. Lee AK, et al. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol. 2003 May;139(1):11-20.

Density	1.4±0.1 g/cm3
Boiling Point	498.1±45.0 °C at 760 mmHg
Melting Point	224-226℃
Molecular Formula	C₂₀H₂₀O₆
Molecular Weight	356.369
Flash Point	220.3±28.8 °C
Exact Mass	356.125977
PSA	63.22000
LogP	3.81
Appearance	white to beige
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.643
Storage condition	2-8°C
Water Solubility	DMSO: soluble5mg/mL, clear (warmed)

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	29329990