873336-87-9

873336-87-9 structure

Name: Muscarinic toxin 3
Chemical Name: Muscarinic toxin 3
CAS Number: 873336-87-9
Molecular Formula: C₃₁₉H₄₈₉N₈₉O₉₇S₈
Molecular Weight: 7379.35
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2023-11-25 19:16:52
Modify Date: 2024-01-27 20:31:31
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC50s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M1, M4, α1A, α1B, α1D,α2A,α2B and α2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity[1].

Name	Muscarinic toxin 3

Description	Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC50s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M1, M4, α1A, α1B, α1D,α2A,α2B and α2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	pIC50: 8.79 (M4 mAChR), 6.71 (M1 mAChR), 8.86 (α1A-adrenoceptor), 8.49 (α2A-adrenoceptor), 8.13 (α1D-adrenoceptor), 7.57 (α1B-adrenoceptor), 7.29 (α2C-adrenoceptor), <6.5 (α2B-adrenoceptor)[1]
References	[1]. Näreoja K, et al. Adrenoceptor activity of muscarinic toxins identified from mamba venoms. Br J Pharmacol. 2011 Sep;164(2b):538-50.

Molecular Formula	C₃₁₉H₄₈₉N₈₉O₉₇S₈
Molecular Weight	7379.35