2306039-13-2

2306039-13-2 structure

Name: Mtb-IN-4
Chemical Name: Mtb-IN-4
CAS Number: 2306039-13-2
Molecular Formula: C₂₄H₁₈N₂O₄S
Molecular Weight: 430.48
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2024-10-05 16:57:32
Modify Date: 2024-10-05 16:57:32
Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant[1].

Name	Mtb-IN-4

Description	Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM). Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Mycobacterium tuberculosis (Mtb)[1]
References	[1]. Sarkar S, et al. Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant. J Med Chem. 2023 Aug 24;66(16):11056-11077.

Molecular Formula	C₂₄H₁₈N₂O₄S
Molecular Weight	430.48