2832966-95-5

2832966-95-5 structure

Name: MB076
Chemical Name: MB076
CAS Number: 2832966-95-5
Molecular Formula: C₉H₁₂BN₇O₅S₂
Molecular Weight: 373.18
Catalog: Research Areas Others
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MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with Ki values ＜ 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility[1].

Name	MB076

Description	MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with Ki values ＜ 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Ki Target: ADC-7, ADC-30, ADC-162, ADC-33, ADC-219, ADC-212[1] Ki: 0.21±0.016 μM (ADC-7), 0.058±0.005μM (ADC-30), 0.79±0.039μM (ADC-162), 0.10±0.004μM (ADC-33), 0.11±0.019 (ADC-219), 0.61±0.038μM (ADC-212)[1]
References	[1]. Rachel A. Powers, et al. Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J Med Chem. 2023 Jul 13; 66(13): 8510–8525.

Molecular Formula	C₉H₁₂BN₇O₅S₂
Molecular Weight	373.18