1802426-00-1
1802426-00-1 structure
- Name: Milvexian TFA
- Chemical Name: Milvexian TFA
- CAS Number: 1802426-00-1
- Molecular Formula: C30H26Cl2F5N9O4
- Molecular Weight: 742.49
- Create Date: 2024-02-01 17:26:19
- Modify Date: 2025-08-25 19:27:27
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Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overallexposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%.
| Name | Milvexian TFA |
|---|
| Description | Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overallexposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%. |
|---|
| Molecular Formula | C30H26Cl2F5N9O4 |
|---|---|
| Molecular Weight | 742.49 |