Milvexian TFA
Modify Date: 2025-08-25 19:27:27
Milvexian TFA structure
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Common Name | Milvexian TFA | ||
|---|---|---|---|---|
| CAS Number | 1802426-00-1 | Molecular Weight | 742.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H26Cl2F5N9O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Milvexian TFAMilvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overallexposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%. |
| Name | Milvexian TFA |
|---|
| Description | Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overallexposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%. |
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| Molecular Formula | C30H26Cl2F5N9O4 |
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| Molecular Weight | 742.49 |