1062172-60-4

1062172-60-4 structure

Name: mTOR inhibitor WYE-28
Chemical Name: mTOR inhibitor WYE-28
CAS Number: 1062172-60-4
Molecular Formula: C₃₀H₃₄N₈O₅
Molecular Weight: 586.64
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2023-11-12 08:56:09
Modify Date: 2024-01-11 22:10:41
mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].

Name	mTOR inhibitor WYE-28

Description	mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer
References	[1]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6.

Molecular Formula	C₃₀H₃₄N₈O₅
Molecular Weight	586.64