2912294-90-5

2912294-90-5 structure

Name: H3B-968
Chemical Name: H3B-968
CAS Number: 2912294-90-5
Molecular Formula: C₂₂H₁₈F₆N₄O₄S
Molecular Weight: 548.46
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2023-09-28 18:11:04
Modify Date: 2024-04-03 12:25:50
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP[1].

Name	H3B-968

Description	H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	Werner syndrome protein (WRN)[1]
References	[1]. Parker MJ, et al. Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay. Biochemistry. 2023 Jul 18;62(14):2147-2160.

Molecular Formula	C₂₂H₁₈F₆N₄O₄S
Molecular Weight	548.46