2861934-86-1

2861934-86-1 structure

Name: Firazorexton hydrate
Chemical Name: Firazorexton hydrate
CAS Number: 2861934-86-1
Molecular Formula: C₂₂H₂₅F₃N₂O₄S_.3/₂H₂O
Molecular Weight: 497.53
Catalog: Signaling Pathways GPCR/G Protein Orexin Receptor (OX Receptor)
Create Date: 2023-10-19 18:37:30
Modify Date: 2024-01-13 06:06:04
Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). Firazorexton hydrate inhibits fragmentation of wakefulness and cataplexy-like episodes in mouse models of narcolepsy[1].

Name	Firazorexton hydrate

Description	Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). Firazorexton hydrate inhibits fragmentation of wakefulness and cataplexy-like episodes in mouse models of narcolepsy[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor) Research Areas >> Neurological Disease
Target	EC50: 19 nM (OX2R)[1]
References	[1]. Ishikawa T, et al. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385(3):193-204.

Molecular Formula	C₂₂H₂₅F₃N₂O₄S_.3/₂H₂O
Molecular Weight	497.53