2409685-41-0

2409685-41-0 structure

Name: Anti-NASH agent 1
Chemical Name: Anti-NASH agent 1
CAS Number: 2409685-41-0
Molecular Formula: C₂₆H₃₃NO₄
Molecular Weight: 423.54
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2023-10-01 09:05:52
Modify Date: 2024-01-12 19:12:26
Anti-NASH agent 1 (compound 3d)，a derivative of Elafibranor (HY-16737)，is a potent agonist of PPAR-α/δ，targeting to nonalcoholic steatohepatitis (NASH). Anti-NASH agent 1 (3-10 mg/kg; 4 weeks) improves hyperlipidemia，liver fat degeneration and liver inflammation in Methionine-choline deficiency (MCD) induced NASH mice model. Anti-NASH agent 1 shows low liver toxicity and potent liver protection effect[1].

Name	Anti-NASH agent 1

Description	Anti-NASH agent 1 (compound 3d)，a derivative of Elafibranor (HY-16737)，is a potent agonist of PPAR-α/δ，targeting to nonalcoholic steatohepatitis (NASH). Anti-NASH agent 1 (3-10 mg/kg; 4 weeks) improves hyperlipidemia，liver fat degeneration and liver inflammation in Methionine-choline deficiency (MCD) induced NASH mice model. Anti-NASH agent 1 shows low liver toxicity and potent liver protection effect[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	PPAR-α/δ[1]
References	[1]. Xiang C, et al. Design, synthesis and anti-NASH effect evaluation of novel GFT505 derivatives in vitro and in vivo. Eur J Med Chem. 2023 Sep 5;257:115510.

Molecular Formula	C₂₆H₃₃NO₄
Molecular Weight	423.54