2101750-19-8

2101750-19-8 structure

Name: 2,4-Difluorophenylethynylcobalamin
Chemical Name: 2,4-Difluorophenylethynylcobalamin
CAS Number: 2101750-19-8
Molecular Formula: C₇₀H₉₁CoF₂N₁₃O₁₄P
Molecular Weight: 1466.45
Catalog: Research Areas Others
Create Date: 2024-01-03 11:29:56
Modify Date: 2024-01-03 11:29:56
2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH)[1].

Name	2,4-Difluorophenylethynylcobalamin

Description	2,4-Difluorophenylethynylcobalamin is a potential B12 antivitamin via binding to human B12 -processing enzyme CblC with high affinity (KD=130 nm). 2,4-Difluorophenylethynylcobalamin withstood tailoring by CblC, and stabilizes the ternary complex with the cosubstrate glutathione (GSH)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	B12 -processing enzyme CblC[1]
References	[1]. Ruetz M, et al. Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7387-7392.

Molecular Formula	C₇₀H₉₁CoF₂N₁₃O₁₄P
Molecular Weight	1466.45