193354-70-0
193354-70-0 structure
- Name: S1R agonist 1
- Chemical Name: S1R agonist 1
- CAS Number: 193354-70-0
- Molecular Formula: C20H25NO
- Molecular Weight: 295.42
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2023-07-18 09:23:18
- Modify Date: 2025-08-26 11:05:53
-
S1R agonist 1 (Compound 6b) is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].
| Name | S1R agonist 1 |
|---|
| Description | S1R agonist 1 (Compound 6b) is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
Sigma 1 Receptor:0.93 nM (Ki) Sigma 2 Receptor:72 nM (Ki) |
| In Vitro | S1R agonist 1 (Compound 6b; 0.1-5 μM) 在 PC12 细胞中能显著增加神经生长因子 (NGF) 诱导的神经突生长，且呈剂量依赖性[1]。 S1R agonist 1 (24 h) 在 SHSY5Y 细胞中浓度为 1 μM 时对 Rotenone (HY-B1756) 诱导的细胞损伤有显著的抑制作用[1]。 S1R agonist 1 (0.1-5 μM; 24 h) 在 SHSY5Y 细胞中对 NMDA 刺激有神经保护作用[1]。 S1R agonist 1 (0-10 μM; 24-72 h) 对 A549、LoVo 和 Panc-1 细胞无细胞毒性[1]。 |
| In Vivo | S1R agonist 1 (Compound 6b; 0.1-50 μM; 120 h) 在 10 μM 下诱导 8 只斑马鱼胚胎中的 4 只死亡[1]。 |
| References |
| Molecular Formula | C20H25NO |
|---|---|
| Molecular Weight | 295.42 |