2435610-93-6

2435610-93-6 structure

Name: PF-07059013
Chemical Name: PF-07059013
CAS Number: 2435610-93-6
Molecular Formula: C₁₉H₁₆FN₅O₂
Molecular Weight: 365.36
Catalog: Research Areas Cardiovascular Disease
Create Date: 2023-06-18 19:38:28
Modify Date: 2024-01-10 23:26:09
PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research[1][2].

Name	PF-07059013

Description	PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vivo	PF-07059013 (10-490 mg/kg，口服灌胃，每日2次，连用2周) 显示 Townes SCD 小鼠的镰刀减少[1]。 Animal Model: Townes SCD mice (8-10 weeks old, male)[1] Dosage: 10, 40, 200, and 490 mg/kg Administration: Oral gavage, twice daily, for 2 weeks Result: Showed a 37.8% (±9.0%) reduction in sickling at 200 mg/kg compared to vehicle treated mice.
References	[1]. Gopalsamy A, et al. PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease. J Med Chem. 2021 Jan 14;64(1):326-342. [2]. Aaron Baldwin, et al. Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture. Org. Process Res. Dev. 2023.

Molecular Formula	C₁₉H₁₆FN₅O₂
Molecular Weight	365.36