PF-07059013
Modify Date: 2024-01-10 23:26:09
PF-07059013 structure
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Common Name | PF-07059013 | ||
|---|---|---|---|---|
| CAS Number | 2435610-93-6 | Molecular Weight | 365.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H16FN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-07059013PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research[1][2]. |
| Name | PF-07059013 |
|---|
| Description | PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research[1][2]. |
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| Related Catalog | |
| In Vivo | PF-07059013 (10-490 mg/kg，口服灌胃，每日2次，连用2周) 显示 Townes SCD 小鼠的镰刀减少[1]。 Animal Model: Townes SCD mice (8-10 weeks old, male)[1] Dosage: 10, 40, 200, and 490 mg/kg Administration: Oral gavage, twice daily, for 2 weeks Result: Showed a 37.8% (±9.0%) reduction in sickling at 200 mg/kg compared to vehicle treated mice. |
| References |
| Molecular Formula | C19H16FN5O2 |
|---|---|
| Molecular Weight | 365.36 |