1354691-97-6
1354691-97-6 structure
- Name: Leniolisib phosphate
- Chemical Name: Leniolisib phosphate
- CAS Number: 1354691-97-6
- Molecular Formula: C21H28F3N6O6P
- Molecular Weight: 548.45
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2023-07-05 13:36:46
- Modify Date: 2024-09-23 18:16:58
-
Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment.
| Name | Leniolisib phosphate |
|---|
| Description | Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate has the potential for immunodeficiency disorders treatment. |
|---|---|
| Related Catalog | |
| Target |
PI3Kδ:11 nM (IC50) PI3Kα:280 nM (IC50) PI3Kβ:480 nM (IC50) PI3Kγ:2.57 nM (IC50) DNA-PK:880 nM (IC50) |
| In Vitro | APDS 突变体 p110δ 在细胞系和患者来源的淋巴细胞中的表达导致通路活性增加，以 AKT 或 S6 的磷酸化来衡量。而 Leniolisib phosphate 以浓度依赖性方式抑制该通路活性[1]。 |
| References |
| Molecular Formula | C21H28F3N6O6P |
|---|---|
| Molecular Weight | 548.45 |