2829349-96-2
2829349-96-2 structure
- Name: FTX-6746
- Chemical Name: FTX-6746
- CAS Number: 2829349-96-2
- Molecular Formula: C16H7ClF2N2O
- Molecular Weight: 316.69
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
- Create Date: 2023-06-29 20:59:01
- Modify Date: 2024-04-03 14:29:44
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FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models[1].
| Name | FTX-6746 |
|---|
| Description | FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models[1]. |
|---|---|
| Related Catalog | |
| Target |
PPARγ |
| In Vivo | FTX-6746 (3-60 mg/kg；口服；每天 2 次，共 21 天) 在小鼠的 UMUC9 或 HT1197 异种移植模型中有显着的肿瘤抑制作用[1]。 Animal Model: UMUC9 or HT1197 xenograft model in NCG or Balb/C nude mice[1] Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg, 60 mg/kg Administration: PO; twice daily for 21 days Result: Resulted >100% tumor growth inhibition at day 21 in HT1197 xenograft model. Resulted up to 80% target gene suppression in tumor tissue at day 2. |
| References |
| Molecular Formula | C16H7ClF2N2O |
|---|---|
| Molecular Weight | 316.69 |