2567494-39-5

2567494-39-5 structure

2567494-39-5 structure

Name: Crozbaciclib fumarate
Chemical Name: Crozbaciclib fumarate
CAS Number: 2567494-39-5
Molecular Formula: C₃₂H₃₄F₂N₆O₄
Molecular Weight: 604.65
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2023-07-09 17:01:18
Modify Date: 2023-07-09 17:01:18
Crozbaciclib fumarate is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively.

Name	Crozbaciclib fumarate

Description	Crozbaciclib fumarate is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	IC50: 3 nM (CDK4), 1 nM (CDK6)[1]
In Vitro	Crozbaciclib fumarate 是一种有效的抗增殖剂，可将 U87MG 细胞系完全抑制在 G1 期（抗增殖试验中的 IC50=15.3 ± 2.9 nM）。 Crozbaciclib fumarate (13.72 nM; 24 h)显着增加 U87MG 细胞中 G1 期细胞的百分比[1]。
In Vivo	Crozbaciclib fumarate (3.125-50 mg/kg) 在多形性胶质母细胞瘤原位异种移植小鼠模型中具有 62% 至 99% 的肿瘤生长抑制值。而 Crozbaciclib fumarate 导致体重减轻不明显。在 50 mg/kg[1] 的剂量下，Crozbaciclib fumarate 显着延长了 162% 的小鼠中载体处理动物的平均存活时间，显着延长了寿命。
References	[1]. Yin L, et al. A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy. Eur J Med Chem. 2018 Jan 20;144:1-28.

Molecular Formula	C₃₂H₃₄F₂N₆O₄
Molecular Weight	604.65