2445335-77-1
2445335-77-1 structure
- Name: Bromodomain IN-2
- Chemical Name: Bromodomain IN-2
- CAS Number: 2445335-77-1
- Molecular Formula: C16H17ClN2O
- Molecular Weight: 288.77
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2023-09-29 21:08:37
- Modify Date: 2024-02-05 19:20:09
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BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity[1].
| Name | Bromodomain IN-2 |
|---|
| Description | BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity[1]. |
|---|---|
| Related Catalog | |
| Target |
BRD4(1):250 nM (Kd) BRPF1b:130 nM (Kd) BRD7:430 nM (Kd) BRD9:67 nM (Kd) BRDT (1):240 nM (Kd) CBP:420 nM (Kd) CECR2:970 nM (Kd) |
| In Vitro | BD-IN-1 (compound 3; 0-100 µM) 具有抗增殖活性，对 SNB-75、UO-31、CAKI-1 细胞和 DU-145、SW-620、NCI-H460 细胞 的 GI50 值分别为 182、479、708 nM 和 13.2、12.0、10.2 µM[1]。 |
| References |
| Molecular Formula | C16H17ClN2O |
|---|---|
| Molecular Weight | 288.77 |