Bromodomain IN-2
Modify Date: 2024-02-05 19:20:09
Bromodomain IN-2 structure
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Common Name | Bromodomain IN-2 | ||
|---|---|---|---|---|
| CAS Number | 2445335-77-1 | Molecular Weight | 288.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17ClN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bromodomain IN-2BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity[1]. |
| Name | Bromodomain IN-2 |
|---|
| Description | BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity[1]. |
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| Related Catalog | |
| Target |
BRD4(1):250 nM (Kd) BRPF1b:130 nM (Kd) BRD7:430 nM (Kd) BRD9:67 nM (Kd) BRDT (1):240 nM (Kd) CBP:420 nM (Kd) CECR2:970 nM (Kd) |
| In Vitro | BD-IN-1 (compound 3; 0-100 µM) 具有抗增殖活性，对 SNB-75、UO-31、CAKI-1 细胞和 DU-145、SW-620、NCI-H460 细胞 的 GI50 值分别为 182、479、708 nM 和 13.2、12.0、10.2 µM[1]。 |
| References |
| Molecular Formula | C16H17ClN2O |
|---|---|
| Molecular Weight | 288.77 |
| InChIKey | DGJREYHVQYZTEV-UHFFFAOYSA-N |
| SMILES | Cc1[nH]c(-c2cc(N)ccc2Cl)c2c1C(=O)CCCC2 |