2402772-30-7

2402772-30-7 structure

Name: ATX inhibitor 18
Chemical Name: ATX inhibitor 18
CAS Number: 2402772-30-7
Molecular Formula: C₂₁H₁₇Cl₂FN₆O
Molecular Weight: 459.30
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2023-07-08 14:55:21
Modify Date: 2024-01-30 11:30:34
ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis[1].

Name	ATX inhibitor 18

Description	ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	Autotaxin:24.2 nM (IC50)
In Vitro	ATX inhibitor 18 (compound 8b) (10 µM; 48 h) 在 CFs、t-HSC/Cl-6 细胞中显示出抗增殖活性[1]。 TX inhibitor 18 (0-4 µM) 具有抗纤维化活性，对 CF、t-HSC/Cl-6 细胞的 IC50 值分别为 0.87 和 1.10 µM[1]。 Cell Viability Assaysup>[1] Cell Line: CFs, t-HSC/Cl-6 cells Concentration: 10 µM Incubation Time: 48 h Result: Showed antiproliferative activity with inhibitory activity of 81.5% and 79.4% for CFs, t-HSC/Cl-6 cells, respectively.
References	[1]. Jiang N, et al. Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis. Eur J Med Chem. 2020 Feb 1;187:111904.

Molecular Formula	C₂₁H₁₇Cl₂FN₆O
Molecular Weight	459.30