ATX inhibitor 18
Modify Date: 2025-09-26 18:53:27
ATX inhibitor 18 structure
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Common Name | ATX inhibitor 18 | ||
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| CAS Number | 2402772-30-7 | Molecular Weight | 459.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H17Cl2FN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ATX inhibitor 18ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis[1]. |
| Name | ATX inhibitor 18 |
|---|
| Description | ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis[1]. |
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| Related Catalog | |
| Target |
Autotaxin:24.2 nM (IC50) |
| In Vitro | ATX inhibitor 18 (compound 8b) (10 µM; 48 h) 在 CFs、t-HSC/Cl-6 细胞中显示出抗增殖活性[1]。 TX inhibitor 18 (0-4 µM) 具有抗纤维化活性，对 CF、t-HSC/Cl-6 细胞的 IC50 值分别为 0.87 和 1.10 µM[1]。 Cell Viability Assaysup>[1] Cell Line: CFs, t-HSC/Cl-6 cells Concentration: 10 µM Incubation Time: 48 h Result: Showed antiproliferative activity with inhibitory activity of 81.5% and 79.4% for CFs, t-HSC/Cl-6 cells, respectively. |
| References |
| Molecular Formula | C21H17Cl2FN6O |
|---|---|
| Molecular Weight | 459.30 |
| InChIKey | ARXKMGRNHJWHRP-YPXUMCKCSA-N |
| SMILES | O=C(NN=Cc1ccc(Cl)cc1)N1CCc2ncnc(Nc3ccc(F)c(Cl)c3)c2C1 |