2309312-85-2

2309312-85-2 structure

Name: Vacquinol-1 dihydrochloride
Chemical Name: Vacquinol-1 dihydrochloride
CAS Number: 2309312-85-2
Molecular Formula: C₂₁H₂₃Cl₃N₂O
Molecular Weight: 425.78
Catalog: Research Areas Cancer
Create Date: 2023-05-20 22:19:32
Modify Date: 2024-01-27 13:38:37
Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 dihydrochloride specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].

Name	Vacquinol-1 dihydrochloride

Description	Vacquinol-1 (NSC13316) dihydrochloride is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 dihydrochloride specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563. [2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137. [3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881. [4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. [5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

Molecular Formula	C₂₁H₂₃Cl₃N₂O
Molecular Weight	425.78