1780303-76-5
1780303-76-5 structure
- Name: DDR1-IN-1 dihydrochloride
- Chemical Name: DDR1-IN-1 dihydrochloride
- CAS Number: 1780303-76-5
- Molecular Formula: C30H33Cl2F3N4O3
- Molecular Weight: 625.51
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Discoidin Domain Receptor
- Create Date: 2019-06-01 12:07:31
- Modify Date: 2024-01-13 15:22:38
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DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1].
| Name | DDR1-IN-1 dihydrochloride |
|---|
| Description | DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM)[1]. |
|---|---|
| Related Catalog | |
| Target |
DDR1:105 nM (IC50) DDR2:413 nM (IC50) |
| In Vitro | DDR1-IN-1 effectively blocks collagen-induced DDR1 pY513 autophosphorylation in U2OS cells (EC50 = 86.76 nM) with excellent selectivity over a panel of >380 kinases. DDR1-IN-1 inhibits DDR2-mediated MT1-MMP activation in human rheumatoid synovial fibroblasts (RASF) upon collagen stimulation (IC50 < 2.5 μM) and enhances PI3K/mTOR inhibitor GSK2126458 antiproliferation efficacy in SNU-1040 colorectal cancer culture[1]. |
| References |
| Molecular Formula | C30H33Cl2F3N4O3 |
|---|---|
| Molecular Weight | 625.51 |