4590-86-7

4590-86-7 structure

Name: DOCK2-IN-1
Chemical Name: DOCK2-IN-1
CAS Number: 4590-86-7
Molecular Formula: C₁₆H₁₁ClN₂O₂
Molecular Weight: 298.72
Catalog: Research Areas Inflammation/Immunology
Create Date: 2023-07-25 12:54:31
Modify Date: 2024-04-06 07:30:56
DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1].

Name	DOCK2-IN-1

Description	DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	DOCK2
References	[1]. Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.

Molecular Formula	C₁₆H₁₁ClN₂O₂
Molecular Weight	298.72