2410846-16-9

2410846-16-9 structure

Name: SIC5-6
Chemical Name: SIC5-6
CAS Number: 2410846-16-9
Molecular Formula: C₂₇H₂₄IN₃O₂S
Molecular Weight: 581.47
Catalog: Research Areas Cancer
Create Date: 2023-04-30 17:48:03
Modify Date: 2024-04-07 18:04:21
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1].

Name	SIC5-6

Description	SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Separase[1]
In Vitro	SIC5-6 (30 μM, 100 μM) 增加 HeLa 细胞中 Caspase-1 活性和 Rad21 裂解。(Rad21：含有与荧光染料 Rh110 (HY-D0817) 结合的 Separase 裂解位点)[1]
References	[1]. Henschke L, et al. Identification of Bioactive Small Molecule Inhibitors of Separase. ACS Chem Biol. 2019 Oct 18;14(10):2155-2159.

Molecular Formula	C₂₇H₂₄IN₃O₂S
Molecular Weight	581.47